Imaging Cartilage Physiology

Molecular imaging with engineered physiology

In vivo imaging techniques are powerful tools for evaluating biological systems. Relating image signals to precise molecular phenomena can be challenging, however, due to limitations of the existing optical, magnetic and radioactive imaging probe mechanisms. Here we demonstrate a concept for molecular imaging which bypasses the need for conventional imaging agents by perturbing the endogenous m...

Cellular Physiology of Articular Cartilage in Health and Disease

HIGHLIGHTED TOPIC Imaging Lung Physiology Imaging for lung physiology: What do we wish we could measure?

Robertson HT, Buxton RB. Imaging for lung physiology: What do we wish we could measure? J Appl Physiol 113: 317–327, 2012. First published May 10, 2012; doi:10.1152/japplphysiol.00146.2012.—The role of imaging as a tool for investigating lung physiology is growing at an accelerating pace. Looking forward, we wished to identify unresolved issues in lung physiology that might realistically be add...

Compositional Magnetic Resonance Imaging Measures of Cartilage

Imaging the Biomechanical Properties of Articular Cartilage

Function: The primary function of articular cartilage is mechanical: under load it must deform to distribute the load over a larger area so as to minimize stress in the underlying bone. In addition, articular cartilage must provide a very low friction surface for gliding when the joint is flexed so that articulating joints move freely. Lastly, it must carry out these two functions for a lifetim...